Methods for suppressing the induction of nitric oxide synthase in a cell
US7049058B2 · kind B2 · utility
44Cited by
11References
47Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 18, 2002 |
| Grant date | May 23, 2006 |
| Priority date | — |
| Expiry date | Mar 20, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/99
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods for suppressing the induction of inducible nitric oxide synthase in a cell comprising contacting said cell with an effective amount of at least one induction suppressor of inducible nitric oxide synthase or a cytokine are disclosed. The induction suppressor can be an inhibitor of mevalonate synthesis, an inhibitor of the farnesylation of Ras, an antioxidant, an enhancer of intracellular cAMP, an enhancer of protein kinase A (PKA), an inhibitor of NF-kβ activation, an inhibitor of Ras/Raf/MAP kinase pathway, an inhibitor of mevalonate pyrophosphate decarboxylase or an inhibitor of farnesyl pyrophosphate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.