Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor

US7049425B2 · kind B2 · utility

Assignee

• WAKE FOREST UNIVERSITY · US

Inventors

• Kenneth T. Wheeler · Winston-Salem, US
• Robert H. Mach · Eureka, US
• Steven R. Childers · Winston-Salem, US
• Gregory Shelness · Winston-Salem, US
• Li-Ming Wang · Taoyuan, TW

Key dates

• Filing date: Mar 30, 2001
• Grant date: May 23, 2006
• Expiry date: Jun 8, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/705
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A new variant of the sigma-1 (σ1)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma—1β (σ1β) finds particular use in the non-invasive diagnosis of cancer and more particularly in the diagnosis of proliferative cancer cells.