Mimetics and inhibitors of the interaction between Vpr (HIV viral protein of regulation) and ANT (Mitochondrial adenine nucleotide translocator)

US7056735B2 · kind B2 · utility

Assignees

• INSTITUT PASTEUR · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE · FR

Inventors

• Etienne Jacotot · Paris, FR
• Guido Kroemer · Paris, FR
• Bernard Roques · Paris, FR
• Lena Edelman · Boulogne, FR
• Johan Hoebeke · Kessel-Lo, BE
• Catherine Brenner-Jean · Survilliers, FR
• Anne-Sophie Belzacq · Neufchâteau, FR

Key dates

• Filing date: Sep 12, 2001
• Grant date: Jun 6, 2006
• Expiry date: Mar 17, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/20
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.