Patent · US Expired

N8 -and c8 -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization

US7063945B2 · kind B2 · utility

1Cited by

1References

3Claims

0Family size

Assignee

Roche Molecular Systems, Inc. · US

Inventors

Frank Seela · Osnabrück, DE
Harald Debelak · Hilden, DE
Frank Bergmann · Iffeldorf, DE
Dieter Heindl · Munich, DE
Herbert von der Eltz · Spaichingen, DE

Key dates

Filing date	Mar 27, 2001
Grant date	Jun 20, 2006
Priority date	—
Expiry date	Sep 19, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H21/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.