Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US7067284B1 · kind B1 · utility
43Cited by
3References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 5, 2000 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Jun 22, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/565
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.