Patent · US Expired

Modulation of telomere length by oligonucleotides having a G-core sequence

US7067497B2 · kind B2 · utility

47Cited by

7References

16Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Ronnie Hanecak · San Clemente, US
Kevin P. Anderson · Carlsbad, US
C. Frank Bennett · Carlsbad, US
Ming-Yi Chiang · Woodbury, US
Vickie Brown-Driver · San Diego, US
David J. Ecker · Encinitas, US
Timothy Vickers · Vista, US
Jacqueline Wyatt · Carlsbad, US

Key dates

Filing date	Jan 2, 2002
Grant date	Jun 27, 2006
Priority date	—
Expiry date	Oct 27, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/346
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.