Regioselective halogenation of nicotine and substituted nicotines
US7067672B2 · kind B2 · utility
5Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 26, 2004 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Aug 26, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/0814
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib:wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.