Mono-acylated o-phenylendiamines derivatives

US7071219B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Georg Fertig · Penzberg, DE
• Frank Herting · Penzberg, DE
• Manfred Kubbies · Penzberg, DE
• Anja Limberg · Penzberg, DE
• Ulrike Reiff · Penzberg, DE
• Michael Weidner · Sunrise, US

Key dates

• Filing date: Feb 3, 2004
• Grant date: Jul 4, 2006
• Expiry date: May 2, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Mono-acylated o-phenylendiamines derivatives of formula Awherein Ar, R1, and R2 are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.