Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations

US7078417B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Rosentreter · Binnen, DE
• Thomas Kramer · Wuppertal, DE
• Andrea Vaupel · Riehen, CH
• Walter Hubsch · Wuppertal, DE
• Nicole Diedrichs · Wuppertal, DE
• Thomas Krahn · Hagen, DE
• Klaus Dembowsky · Boston, US
• Johannes-Peter Stasch · Wuppertal, DE
• Mitsuyuki Shimada · Nara, JP

Key dates

• Filing date: Mar 19, 2002
• Grant date: Jul 18, 2006
• Expiry date: Mar 19, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This application relates to pyridine derivatives having the general structurein which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmacutical composition containing such compounds, and a method for using these materials for treatment of stable and unstable angina pectoris and atrial fibrillation.