Vascular endothelial cell growth factor variants and uses thereof
US7090834B1 · kind B1 · utility
4Cited by
1References
55Claims
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Key dates
| Filing date | Apr 10, 2000 |
| Grant date | Aug 15, 2006 |
| Priority date | — |
| Expiry date | Apr 10, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides VEGF variants having one or more amino acid mutations in the KDR and/or FLT-1 receptor binding domains in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.