Bacterial strains which overproduce riboflavin and methods of use thereof

US7091000B2 · kind B2 · utility

Assignee

• DSM Nutritional Products, LLC · US

Inventors

• John B. Perkins · Reading, US
• Alan Sloma · Davis, US
• Janice G. Pero · Lexington, US
• Randolph T. Hatch · Wellesley, US
• Theron Hermann · Arlington, US
• Thomas Erdenberger · Arlington, US

Key dates

• Filing date: Feb 10, 2003
• Grant date: Aug 15, 2006
• Expiry date: Mar 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/52
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.