Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors

US7091229B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Guy Georges · Habach, DE
• Adelbert Grossmann · Murnau am Staffelsee, DE
• Olaf Mundigl · Weilheim, DE
• Wolfgang von der Saal · Rosenheim, DE
• Tim Sattelkau · Ludwigshafen, DE

Key dates

• Filing date: Jan 24, 2002
• Grant date: Aug 15, 2006
• Expiry date: Jan 13, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I)wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.