Thiophene hydroxamic acid derivatives

US7098241B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Adelbert Grossmann · Murnau am Staffelsee, DE
• Frank Herting · Penzberg, DE
• Matthias Koerner · Antdorf, DE
• Klaus-Peter Kuenkele · Perchtoldsdorf, AT
• Anja Limberg · Penzberg, DE
• Olaf Mundigl · Weilheim, DE
• Ulrich Tibes · Starnberg, DE

Key dates

• Filing date: Dec 10, 2003
• Grant date: Aug 29, 2006
• Expiry date: Feb 6, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The (R) and (S) enantiomers of a compound of formula Iare novel antiproliferative therapeutic agents. These compounds have HDAC inhibitor activity and are useful in the treatment of cancer. Also disclosed are methods of making and using compounds of formula (I), as well as pharmaceutical compositions containing compounds of formula (I).