PD-1, a receptor for B7-4, and uses therefor
US7101550B2 · kind B2 · utility
151Cited by
2References
5Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Feb 6, 2002 |
| Grant date | Sep 5, 2006 |
| Priority date | — |
| Expiry date | Nov 20, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.