Inventor · Brookline, MA, US

Gordon J. Freeman

91Patents
26h-index
99Co-inventors
91Inventor score

Filing activity: Jan 8, 1976 → Sep 22, 2022

Most-cited inventions

PatentTitleAreaCited byStatus
US5858358A Methods for selectively stimulating proliferation of T cells Chemistry; Metallurgy 299 Expired
US6808710B1 Downmodulating an immune response with multivalent antibodies to PD-1 Physics 278 Expired
US8552154B2 Anti-PD-L1 antibodies and uses therefor Emerging Cross-Sectional Technologies 189 Active
US7101550B2 PD-1, a receptor for B7-4, and uses therefor Physics 151 Expired
US7635757B2 B7-4 Antibodies and uses therefor Chemistry; Metallurgy 142 Active
US7105328B2 Methods for screening for compounds that modulate pd-1 signaling Physics 110 Expired
US6936704B1 Nucleic acids encoding costimulatory molecule B7-4 Chemistry; Metallurgy 103 Expired
US7709214B2 Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1 Physics 84 Active
US7038013B2 B7-4 polypeptides and uses therefor Chemistry; Metallurgy 77 Expired
US7722868B2 Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof Physics 69 Active
US9683048B2 Antibody molecules to PD-1 and uses thereof Emerging Cross-Sectional Technologies 66 Active
US7638492B2 Methods of upmodulating an immune response with non-activating forms of B7-4 Physics 64 Active
US6719972B1 Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies Chemistry; Metallurgy 62 Expired
US9102727B2 Human anti-PD-1 antibodies and uses therefor Emerging Cross-Sectional Technologies 61 Active
US5942607A B7-2: a CTLA4/CD28 ligand Chemistry; Metallurgy 57 Expired
US7432059B2 Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal Physics 56 Expired
US5861310A Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor Chemistry; Metallurgy 56 Expired
US8652465B2 Methods and compositions for the treatment of persistent infections Emerging Cross-Sectional Technologies 51 Active
US9605070B2 Antibody molecules to TIM-3 and uses thereof Emerging Cross-Sectional Technologies 50 Active
US7470428B2 Compositions and methods related to TIM-3, a Th1-specific cell surface molecule Chemistry; Metallurgy 40 Expired
US6130316A Fusion proteins of novel CTLA4/CD28 ligands and uses therefore Chemistry; Metallurgy 36 Expired
US5858776A Tumor cells with increased immunogenicity and uses therefor Human Necessities 33 Expired
US8101176B2 Compositions and methods related to TIM-3, a TH1-specific cell surface molecule Chemistry; Metallurgy 31 Active
US7700301B2 Methods for screening for compounds that modulate PD-1 signaling Physics 30 Active
US8709412B2 Modulation of TIM receptor activity in combination with cytoreductive therapy Chemistry; Metallurgy 29 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.