Cyclohexyl sulphone derivatives as gamma-secretase inhibitors
US7101895B2 · kind B2 · utility
16Cited by
2References
8Claims
0Family size
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Key dates
| Filing date | Oct 6, 2003 |
| Grant date | Sep 5, 2006 |
| Priority date | — |
| Expiry date | Apr 7, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula I:wherein Ar1 and Ar2 are optionally substituted aryl or heteroaryl, L is a bond, ═CH— or —(CHRa)n—, and X is SCN, SR1, S(O)R1, (CRaRb)mSO2R1, SO2N(R2)2, SO2NHCOR1, SO2NHN(R2)2, OSO2N(R2)2, OS(O)N(R2)2, OSO2NHCOR1, COR4, NHCOR1, NHCO2R1, NHCON(R2)2, NHSO2R1 or NHSO2N(R2)2, inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.