G protein-coupled receptor antagonists

US7105488B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Nadya I. Tarasova · Frederick, US
• Christopher J. Michejda · North Potomac, US

Key dates

• Filing date: Feb 26, 1999
• Grant date: Sep 12, 2006
• Expiry date: Feb 26, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

G-protein coupled receptors (GPCR) generally contain seven transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides inhibit GPCR function by disrupting GPCR structure. In certain embodiments, charged residues are added at one terminus to promote correct orientation of the peptide in the membrane.