Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR)

US7122570B2 · kind B2 · utility

Assignee

• Zentaris GmbH · DE

Inventors

• Marcus Koppitz · Berlin, DE
• Hans-Peter Muhn · Berlin, DE
• Kenneth J. Shaw · Califon, US
• Holger HESS-STUMP · Berlin, DE
• Klaus Paulini · Maintal, DE

Key dates

• Filing date: Dec 16, 2002
• Grant date: Oct 17, 2006
• Expiry date: Apr 12, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides new tetrahydrocarbazole derivatives that act as ligands for G-protein-coupled receptors (GPCR), especially as antagonists of the gonadotropin-releasing hormone (GnRH). A pharmaceutical composition that contains these new tetrahydrocarbazole derivatives as well as a process for the production of the new tetrahydrocarbazole derivatives are also provided. Moreover, this invention relates to the administration of tetrahydrocarbazole derivatives for treating pathologic conditions that are mediated by GPCR, especially for inhibiting GnRH, in mammals, especially humans, who require such an administration, as well as the use of tetrahydrocarbazole derivatives for the production of a pharmaceutical agent for treating GPCR-mediated pathologic conditions, especially for inhibiting GnRH.