Effector conjugates, process for their production and their pharmaceutical use

US7129254B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Markus Berger · Berlin, DE
• Gerhard Siemeister · Berlin, DE
• Ulrich Klar · Berlin, DE
• Jörg Willuda · Berlin, DE
• Andreas Menrad · Berlin, DE
• Klaus Bosslet · Marburg, DE

Key dates

• Filing date: Jul 31, 2003
• Grant date: Oct 31, 2006
• Expiry date: Dec 4, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.