Patent · US Expired

Biosynthetic binding proteins for immuno-targeting

US7138497B2 · kind B2 · utility

7Cited by
14References
2Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJun 21, 2001
Grant dateNov 21, 2006
Priority date—
Expiry dateOct 27, 2023

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/55
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic construct for binding at least one preselected antigen. The biosynthetic construct contains two polypeptide chains, each of which define single-chain Fv (sFv) binding proteins and have C-terminal tails that facilitate the crosslinking of two sFv polypeptides. The resulting dimeric constructs have a conformation permitting binding of a said preselected antigen by the binding site of each said polypeptide chain when administered to said mammal. The formulation has particular utility in in vivo imaging and drug targeting experiments.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.