Synthesis and screening of ligands using X-ray crystallography
US7149280B2 · kind B2 · utility
0Cited by
5References
12Claims
0Family size
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Key dates
| Filing date | Dec 22, 2003 |
| Grant date | Dec 12, 2006 |
| Priority date | — |
| Expiry date | Dec 22, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6803
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.