Attenuated human rotavirus vaccine

US7150984B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Yasutaka Hoshino · Wheaton, US
• Albert Z. Kapikian · Rockville, US
• Robert M. Chanock · Bethesda, US

Key dates

• Filing date: Jul 11, 1995
• Grant date: Dec 19, 2006
• Expiry date: Jul 11, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2720/12364
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating mutations which produce virus having a cold-adapted (ca) and temperature sensitive (ts) phenotype. The attenuated strains are used in methods for stimulating the immune system of an individual to induce protection against human rotavirus by administration of the ca attenuated rotavirus.