Thiocarbamate inhibitors of alpha-4 integrins
US7166600B2 · kind B2 · utility
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12References
20Claims
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Assignee
Inventor
Key dates
| Filing date | Jan 11, 2006 |
| Grant date | Jan 23, 2007 |
| Priority date | — |
| Expiry date | Jan 11, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1–R4, m, n, o and p are as defined herein. Also provided are compositions comprising compounds of formula I and a carrier, diluent or excipient as well as methods of treating a disease or condition mediated by the binding interaction of alpha-4 integrins to its ligands such as inflammatory diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.