Anti-VEGF antibodies

US7169901B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Manuel Baca · Gaithersburg, US
• James A. Wells · Burlingame, US
• Leonard G. Presta · San Francisco, US
• Henry B. Lowman · El Granada, US
• Yvonne Chen · San Mateo, US

Key dates

• Filing date: Sep 3, 2002
• Grant date: Jan 30, 2007
• Expiry date: Aug 20, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.