Patent · US Expired

Modified factor VIIa

US7173000B2 · kind B2 · utility

16Cited by
5References
15Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 9, 2001
Grant dateFeb 6, 2007
Priority date—
Expiry dateJan 16, 2023

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y304/21021
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A modified factor VIIa is provided. The modified factor has increased amidolytic activity in the absence of T.F. and a higher affinity for T.F. when compared to the native factor VIIa but does not have substantially altered proteolytic activity when bound to T.F. Nucleic acid molecules that encode the factor, expression vectors that contain the nucleic acid molecules, cells that contain the nucleic acid molecules, and cells transformed with the expression vector are also provided. In a preferred embodiment, the modified factor is a human factor VIIa.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.