Compounds and methods for modulating activation of NF-κB
US7186503B2 · kind B2 · utility
1Cited by
17References
4Claims
0Family size
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Key dates
| Filing date | Sep 19, 2003 |
| Grant date | Mar 6, 2007 |
| Priority date | — |
| Expiry date | Nov 17, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.