Methods of screening and diagnostics using ATP-binding cassette transporter

US7189511B2 · kind B2 · utility

Assignees

• Baylor College of Medicine · US
• The United States of America, as represented by the Department of Health and Human Services · US
• University of Utah Research Foundation · US
• The John Hopkins University · US

Inventors

• Rando Allikmets · Frederick, US
• Kent L. Anderson · Houston, US
• Michael Dean · Frederick, US
• Mark Leppert · Salt Lake City, US
• Richard A. Lewis · Houston, US
• Yixin Li · Houston, US
• James R. Lupski · Houston, US
• Jeremy Nathans · Baltimore, US
• Amir Rattner · Baltimore, US
• Noah F. Shroyer · Houston, US
• Nanda Singh · Salt Lake City, US
• Philip Smallwood · Woodbine, US
• Hui Sun · Culver City, US

Key dates

• Filing date: Jan 3, 2003
• Grant date: Mar 13, 2007
• Expiry date: Jan 24, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01K2217/05
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.