Inhibitors of p38

US7205305B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Guy Bemis · Arlington, US
• Francesco G. Salituro · Marlborough, US
• John P. Duffy · Westborough, US
• John Cochran · North Andover, US
• Edmund Harrington · Plymouth, US
• Mark A. Murcko · Holliston, US
• Keith P. Wilson · Hopkinton, US
• Michael Su · Newton, US
• Vincent Galullo · Harvard, US

Key dates

• Filing date: Jul 17, 2003
• Grant date: Apr 17, 2007
• Expiry date: Sep 17, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.