Aniline derivatives, their manufacture and use as pharmaceutical agents

US7205326B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Birgit Bossenmaier · Hanerau-Hademarschen, DE
• Walter-Gunar Friebe · Mannheim, DE
• Ulrike Reiff · Penzberg, DE
• Matthias Rueth · Penzberg, DE
• Edgar Voss · Bichl, DE

Key dates

• Filing date: Apr 28, 2004
• Grant date: Apr 17, 2007
• Expiry date: Oct 5, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I)are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.