Patent · US Expired

Imidazole and benzimidazole caspase inhibitors and uses thereof

US7205327B2 · kind B2 · utility

6Cited by
2References
11Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 19, 2001
Grant dateApr 17, 2007
Priority date—
Expiry dateNov 21, 2022

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02A50/30
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

This invention provides caspase inhibitors having the formula:wherein R1 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R2 and R3 are each independently selected from hydrogen or an optionally substituted C1–C6 aliphatic group; and R4 and R5 are each independently selected from hydrogen, an optionally substituted C1–C6 aliphatic group, or R4 and R5 taken together with the ring to which they are attached form an optionally substituted bicyclic ring. The caspase inhibitors are useful for treating a number of diseases such as cancer, acute inflammatory and autoimmune disorders, ischemic diseases and certain neurodegenerative disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.