N-monoacylated o-phenylenediamines

US7208491B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Georg Fertig · Penzberg, DE
• Frank Herting · Penzberg, DE
• Manfred Kubbies · Penzberg, DE
• Anja Limberg · Penzberg, DE
• Ulrike Reiff · Penzberg, DE
• Michael Weidner · Sunrise, US

Key dates

• Filing date: Feb 3, 2004
• Grant date: Apr 24, 2007
• Expiry date: Mar 18, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/85
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Mono-acylated o-phenylendiamines derivatives of formula Iwherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.