Pyridine-3-carboxamide derivatives as CB1 inverse agonists

US7229999B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Paul Hebeisen · Basel, CH
• Hans Iding · Rheinfelden (Baden), DE
• Matthias Nettekoven · Weil am Rhein, DE
• Ulrike Obst · Weil am Rhein, DE
• Stephan Roever · Inzlingen, DE
• Beat Wirz · Basel, CH

Key dates

• Filing date: Apr 4, 2006
• Grant date: Jun 12, 2007
• Expiry date: Apr 4, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formulawherein X and R1 to R8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors, such as obesity.