Fermentation process using specific oxygen uptake rates as a process control
US7232664B2 · kind B2 · utility
15Cited by
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15Claims
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Key dates
| Filing date | May 30, 2003 |
| Grant date | Jun 19, 2007 |
| Priority date | — |
| Expiry date | Nov 3, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.