Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues

US7241765B2 · kind B2 · utility

Assignee

• Neurogen Corporation · US

Inventors

• Alan Hutchison · Madison, US
• Linda M. Gustavson · Guilford, US
• John M. Peterson · Madison, US
• Dario Doller · Wallingford, US
• Timothy Caldwell · Fishers, US
• Taeyoung Yoon · Pasadena, US
• Wallace Pringle · Guilford, US
• Rajagopal Bakthavatchalam · Branford, US
• Yiping Shen · Branford, US
• Cheryl Steenstra · Meriden, US
• Helen Yin · Orlando, US
• Robert W. DeSimone · Durham, US
• Xiao He · Branford, US

Key dates

• Filing date: May 17, 2006
• Grant date: Jul 10, 2007
• Expiry date: May 17, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).