Microorganisms and processes for enhanced production of pantothenate
US7244593B2 · kind B2 · utility
3Cited by
3References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 2002 |
| Grant date | Jul 17, 2007 |
| Priority date | — |
| Expiry date | Dec 7, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y603/02001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.