Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response
US7250404B2 · kind B2 · utility
78Cited by
28References
15Claims
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Key dates
| Filing date | Jul 26, 2002 |
| Grant date | Jul 31, 2007 |
| Priority date | — |
| Expiry date | Jul 26, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.