Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

US7253281B2 · kind B2 · utility

Assignees

• Hoffmann-La Roche Inc. · US
• Vernalis Research Limited · GB

Inventors

• Jonathan Mark Bentley · Wokingham, GB
• Paul Hebeisen · Basel, CH
• Patrizio Mattei · Riehen, CH
• Marc Muller · Wolfersdorf, FR
• Hans Richter · Weil am Rhein, DE
• Stephan Roever · Inzlingen, DE
• Sven Taylor · Riedisheim, FR

Key dates

• Filing date: Jun 28, 2005
• Grant date: Aug 7, 2007
• Expiry date: Jun 28, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.