Regiospecific synthesis of rapamycin 42-ester derivatives
US7268144B2 · kind B2 · utility
12Cited by
11References
14Claims
0Family size
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Key dates
| Filing date | Apr 12, 2005 |
| Grant date | Sep 11, 2007 |
| Priority date | — |
| Expiry date | Jun 22, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/188
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.