Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
US7273844B2 · kind B2 · utility
94Cited by
3References
10Claims
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Key dates
| Filing date | Nov 4, 2004 |
| Grant date | Sep 25, 2007 |
| Priority date | — |
| Expiry date | Sep 21, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An isolated, water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide has the amino acid residue sequence shown in SEQ ID NO: 7, SEQ ID NO: 12, or an angiogenesis inhibiting fragment thereof, the fragment including at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). Methods of using the polypeptide to inhibit angiogenesis are also provided.
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