Compositions and methods for inducing osteogenesis

US7273864B2 · kind B2 · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Xu Wu · San Diego, US
• Sheng Ding · San Diego, US
• Nathanael S. Gray · Boston, US

Key dates

• Filing date: Oct 15, 2003
• Grant date: Sep 25, 2007
• Expiry date: Oct 15, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/40
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage, using compounds of the following formula:wherein R4 is a functional group including, for example, C1-4alkyl, C3-8cycloalkyl, hydroxyl-C1-4alkyl, aryl-C0-3alkyl, substituted with 0-2 R4a groups, and heterocyclo-C0-2alkyl, optionally substituted with C1-4alkyl; R5 is hydrogen and R6 is a functional group including, for example, halogen, C1-4alkyl, —C(O)—C1-4alkyl, —SO2—N(R2b R2b), halo—C1-4alkyl, —O-aryl and —N(R7 R8), or when R5 and R6 are on adjacent ring atoms they are optionally taken together to form —O—(CH2)1-2—O—; and all pharmaceutically acceptable salts and hydrates thereof.