HIV replication inhibitors

US7276510B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Michael Joseph Kukla · Masontown, US
• Donald Ludovici · Quakertown, US
• Robert W. Kavash · Glenside, US
• Bart De Corte · Southampton, US
• Jan Heeres · Vosselaar, BE
• Paul Adriaan Jan Janssen · Vosselaar, BE
• Lucien Maria Henricus Koymans · Retie, BE
• Marc René de Jonge · Tilburg, NL
• Koen Jeanne Alfons Van Aken · Kortrijk, BE
• Alain Krief · Wépion, BE
• Ruben Gerardus George Leenders · Nijmegen, NL

Key dates

• Filing date: May 3, 2001
• Grant date: Oct 2, 2007
• Expiry date: Mar 14, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention concerns HIV replication inhibitors of formulathe N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, provided that when Q is halo then Z is N; or when Q is polyhaloC1-6alkyl then Y is hydrogen or C1-6alkyl; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.