Macrocyclic pyrimidines, their production and use as pharmaceutical agents

US7312225B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Ulrich Luecking · Berlin, DE
• Gerhard Siemeister · Berlin, DE
• Martina Schaefer · Berlin, DE
• Hans Briem · Bremen, DE

Key dates

• Filing date: Aug 20, 2003
• Grant date: Dec 25, 2007
• Expiry date: Dec 24, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Macrocyclic pyrimidine derivatives of general formula Iin which R1 to R5, X, Y, A, B, m and n have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinase, their processes for production as well as their use as medications for treating various diseases are described.