Quinolinone derivatives as inhibitors of c-fms kinase

US7326788B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Mark Wall · Lansdale, US
• Mark R. Player · Phoenixville, US
• Raymond J. Patch · Yardley, US
• Sanath K. Meegalla · Boothwyn, US
• Jian Liu · Xi'an, CN
• Carl R. Illig · Phoenixville, US
• Wing S. Cheung · Plainsboro, US
• Jinsheng Chen · Exton, US
• Davoud Asgari · Wilmington, US

Key dates

• Filing date: Jul 20, 2004
• Grant date: Feb 5, 2008
• Expiry date: Jun 28, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to compounds of Formulae I and II:wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.