Adamantyl acetamides as 11-beta hydroxysteroid dehydrogenase inhibitors

US7332524B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Joannes Theodorus Maria Linders · Eindhoven, NL
• Gustaaf Henri Maria Willemsens · Beerse, BE
• Ronaldus Arnodus Hendrika Joseph Gilissen · Beerse, BE
• Christophe Francis Robert Nestor Buyck · Temse, BE
• Greta Constantia Peter Vanhoof · Zoersel, BE
• Louis Jozef Elisabeth Van Der Veken · Vosselaar, BE
• Libuse Jaroskova · Vosselaar, BE

Key dates

• Filing date: Dec 16, 2003
• Grant date: Feb 19, 2008
• Expiry date: Dec 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydrogen C1-4alkyl, NR9R10, C1-4alkyloxy; or R1 and R2 taken together with the carbon atom with which they are attached form a C3-6cycloalkyl; and where n is 2, either R1 or R2 may be absent to form an unsaturated bond; R3 represents a C6-12cycloalkyl, preferably selected from cylo-octanyl and cyclohexyl or R3 represents a monovalent radical having one of the following formulae