Screening assays for compounds that cause apoptosis

US7338807B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Curtis C. Harris · Bethesda, US
• Xin Wang · Beijing, CN
• Jan H. J. Hoeijmakers · Zevenhuizen, NL

Key dates

• Filing date: Aug 4, 2003
• Grant date: Mar 4, 2008
• Expiry date: Sep 11, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.