Fatty-acid amide hydrolase
US7348173B2 · kind B2 · utility
30Cited by
1References
3Claims
0Family size
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Key dates
| Filing date | Feb 26, 2004 |
| Grant date | Mar 25, 2008 |
| Priority date | — |
| Expiry date | Dec 8, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/6418
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a compound without soporific activity. FAAH has be isolated and the gene encoding FAAH has been cloned, sequenced, and used to express recombinant FAAH. Inhibitors of FAAH are disclosed to block the hydrolase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.