Self-assembling recombinant papillomavirus capsid proteins

US7361356B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• Deutsches Krebsforschungszentrum, The German Cancer Research Center · DE

Inventors

• Douglas R. Lowy · Washington, US
• John T. Schiller · Silver Spring, US
• Reinhard Kirnbauer · Bethesda, US

Key dates

• Filing date: Jun 9, 2006
• Grant date: Apr 22, 2008
• Expiry date: Jun 9, 2026

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/927
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.