Respiratory syncytial virus replication inhibitors

US7361657B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Frans Eduard Janssens · Bonheiden, BE
• Kathleen Petrus Marie-José Meersman · Wechelderzande, BE
• François Maria Sommen · Wortel, BE
• Jérôme Emile Georges Guillemont · Andé, FR
• Jean Fernand Armand Lacrampe · Le Mesnil-Esnard, FR
• Koenraad Jozef Lodewijk Marcel Andries · Beerse, BE

Key dates

• Filing date: Jan 12, 2006
• Grant date: Apr 22, 2008
• Expiry date: Jan 14, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention concerns the use of compounds of formula (I) wherein −a1=a2−a3=a4—is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—CH═N—wherein each hydrogen atom may optionally be substituted; Q is a radical of formulas (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), G is a direct bond or C1-10alkanediyl; R1 is an optionally substituted monocyclic heterocycle; for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections. Certain compounds of formula (I) are new