Vasoregulating compounds and methods of their use

US7364719B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Frank Cuttitta · Adamstown, US
• Alfredo Martinez · Chihuahua, MX
• William G. Stetler-Stevenson · Kensington, US
• Edward Unsworth · Kensington, US
• Juan M. Saavedra · Bethesda, US

Key dates

• Filing date: Oct 3, 2003
• Grant date: Apr 29, 2008
• Expiry date: Mar 30, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a therapeutically effective amount peptide AM(11-22). The vasoconstrictor can be used for a variety of purposes, including hemostasis or the treatment of shock, for example vasodilatory shock syndromes such as septic shock. Other specific embodiments are methods for reversing vasoconstriction of blood vessels, by administering to a subject a therapeutically effect amount of an inhibitor of AM(11-22), sufficient to reduce hypertension in the subject. Compounds and pharmaceutical compositions are also provided, as are kits.