Alternatively spliced nucleic acid molecules
US7368553B2 · kind B2 · utility
0Cited by
0References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 21, 2004 |
| Grant date | May 6, 2008 |
| Priority date | — |
| Expiry date | Oct 6, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides an isolated or purified nucleic acid molecule comprising SEQ ID NO:1, which contains cDNA comprising exons 1-5 of a vascular endothelial growth factor (VEGF) joined to genomic DNA comprising introns 5, 6, and 7 and exons 6, 7, and 8 of VEGF and a mutation in one or more of the splice donor, branch point, and splice acceptor regions, which promotes the production of a VEGF189 isoform. Expression constructs, compositions, and cells comprising such a nucleic acid molecule also are provided by the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.